Courtney Sexton, Smithsonian Magazine, 18 Sep. 2023 Currently, only three dyes with fluorescent properties used as optical imaging contrast agents- methylene blue, indocyanine green and fluorescein-are approved for human use by the U.S. 2023 To gauge the fat content of the cream brought by farmers, the dairy would insert methylene blue in a sample and waited for its lactic acid to dissolve the color.
These results indicate that metHb-albumin clusters could be a more effective and safer antidote against cyanide poisoning than NaNO 2.Recent Examples on the Web To gauge the fat content of the cream brought by farmers, the dairy would insert methylene blue in a sample and waited for its lactic acid to dissolve the color. Furthermore, the oxygen carrying capacity was maintained in poisoned mice treated with metHb-albumin clusters and was low in those treated with NaNO 2. In mice subjected to cyanide poisoning, metHb-albumin clusters reduced mortality and alleviated metabolic acidosis, while maintaining the activity of cytochrome c oxidase in organs their efficacy was better than that of NaNO 2. In vitro cell experiments showed that metHb-albumin clusters prevented the cyanide-induced inhibition of cytochrome c oxidase activity, resulting in a strong cytoprotective effect.
Spectral analyses proved that the metHb-albumin clusters possessed cyanide-binding properties similar to those of naked metHb.
The metHb-albumin cluster is made by a metHb core wrapped by covalently bound human serum albumin. Herein, we present a promising antidote: methemoglobin (metHb)-albumin clusters. However, its use has serious drawbacks in terms of efficacy and safety. Sodium nitrite (NaNO 2) is a universal antidote for patients with cyanide poisoning.
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